Cell‐specific ATP7A transport sustains copper‐dependent tyrosinase activity in melanosomes
نویسندگان
چکیده
منابع مشابه
Tyrosinase Depletion Prevents the Maturation of Melanosomes in the Mouse Hair Follicle
The mechanisms that lead to variation in human skin and hair color are not fully understood. To better understand the molecular control of skin and hair color variation, we modulated the expression of Tyrosinase (Tyr), which controls the rate-limiting step of melanogenesis, by expressing a single-copy, tetracycline-inducible shRNA against Tyr in mice. Moderate depletion of TYR was sufficient to...
متن کاملOrganelle Transport: A Park-and-Ride System for Melanosomes
Those of us experiencing graying hair may be more sensitive to the term melanosome than other readers. You will find no remedy within this article, but rather a jealous look at the organisms which are able to manipulate their skin color, for example to match the appearance of their environment. In fish and amphibians, this change is brought about by movements of pigment-containing vesicles, mel...
متن کاملThe inhibition effects of melon on mushroom tyrosinase activity
The inhibition effects seed and peel of melon on diphenolase activity of mashroom tyrosinase were investigated. The IC50 values and Ki values of seed and peel of melon were evaluated. increased the Km value and decreased the Vm value so it show mixed type inhibition on mushroom tyrosinase when L-DOPA was used as a substrate.
متن کاملThe tyrosine hydroxylase activity of mammalian tyrosinase.
The tyrosine hydroxylase activity of tyrosinase from hamster melanoma has been studied by measurement of the release of tritium from tyrosine-3,5-3H. Experiments with mixtures of tyrosine3 ,5-3H and tyrosine-r4C show that there is little or no tritium rate effect in this reaction. Dopa is the most effective hydrogen donor and will eliminate the lag period when used in catalytic amounts. 2-Amino...
متن کاملStructural and Activity Comparison of Native, Apo and Reconstituted Tyrosinase
Background: Mushroom Tyrosinase a potent candidate in clinical studies known as polyphenol oxidase, is a metaloenzyme from the oxidase superfamily widely distributed from lower to higher life forms. It plays a crucial role in sclerotization of exoskeleton in insects, also responsible for skin pigmentation in mammalians. Objective: In this study, after reconstitution of MT by some metal io...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.866.3